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In our article ”What do I feed my dog now?” Katie and I had discussed what to buy for your dog. There have been lots of reports over poisonous ingredients that were/are being used to formulate certain brands of dog food. We didn’t name the brands b

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ut we told you our secret brand for a happy strong dog.

If you’ve read the article you’ll also remember Katie left us hanging with this line at the end “And remember, no chocolate, no onions, no raisins, no grapes, and one I just learned about is no

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

avocados.” I wanted to know “why?” So… In this article we will discuss the foods that we humans eat with relatively no consequences but can be harmful even deadly for your dog. Some of these will surprise you.

Alcohol: Ingestion can lead to sick

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ness, urination problems or even coma or death from alcohol poisoning.

Anti-freeze: Although not a human food, it can be readily available for them in a car park puddle. It is sweet so if they find it, they will drink it. Even a small amount of ant

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

freeze can be fatal. 3-4 tablespoons can kill a medium sized dog. The main ingredient in antifreeze is ethylene glycol, an extremely toxic poison that causes kidney failure, which is often fatal in just a few days.

Apple: The seeds contain cyanogeni

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

glycosides, which can result in cyanide poisoning. Any seed or pit from a fruit is dangerous.

Apricot: Same as the apple.

Avocado: Avocadoes are high in fat content and can trigger an upset stomach, vomiting or even pancreatitis. Avocado contains

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

a toxic element called persin, which can damage heart, lung and other tissue in many animals.

Baby Food: If it contains onion powder then it is not good. See onions for more explanations.

Bones: Cooked bones can be very hazardous for your dog.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hey become brittle and can splinter causing your dog to choke or worst, puncture, rupture their stomach lining and intestinal tract. Bad bones are turkey and chicken legs, ham, pork chop and veal.

Bread Dough: Pets who have eaten bread dough may exp

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

erience abdominal pain, bloat, vomiting, disorientation and depression. When bread dough is ingested your dog's body heat causes the dough to rise in the stomach. During the rising process alcohol is produced as the dough expands.

Candy: Sugarless

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

andy containing xylitol has been recognized by the National Animal Poison Control Center (NAPCC) to be a risk to pets. The compound can cause liver damage.

Cherries: The seed pit contains cyanogenic glycosides which can cause cyanide poisoning.

Ch

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

colate: Chocolate contains theobromine, a compound that is a cardiac stimulant and a diuretic. Theobromine will either increase the dog’s heart rate or may cause the heart to beat irregularly. Death is quite possible, especially with exercise.

Eggs

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

(Raw): Raw egg whites contain a protein called avidin, which can deplete your dog of biotin, one of the B vitamins. Biotin is essential to your dog’s growth and coat health. Additionally, raw eggs are often contaminated with bacteria, such as salmone

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

la, and you could end up giving your dog food poisoning in addition to biotin deficiency.

Grapes or Raisins: Although the minimum lethal dosage is not known, grapes and raisins can be toxic to dogs when ingested in large quantities. The symptoms are

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

gastrointestinal signs including vomiting and diarrhea, and then signs of kidney failure with an onset of severe kidney signs starting about 24 hours after ingestion.

Liver: In small amounts liver is good for your dog, but if the liver intake is to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

high it can cause nutritional problems because liver has a high content of vitamin A. Consumption of this vitamin in large amounts can lead to vitamin A toxicity, or hypervitaminosis A. It could lead to bone problems.

Macadamia Nuts: The toxic comp

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

und is unknown but eating as few as six nuts without the shell has been known to cause elevated body temperature, accelerated heartbeat, tremors in the skeletal muscles, and weakness or paralysis of the hindquarters.

Onions: Onions cause hemolytic a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nemia. Red blood cells break down leaving the dog short of oxygen. Onion poisoning can occur with a single ingestion of large quantities or with repeated meals containing small amounts of onion.

Salmon (Raw): The cause is infection by a rickettsial

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

organism called Neorickettsia helminthoeca. A sudden onset of symptoms occurs 5-7 days after ingestion of fish. Initial symptoms include lethargy and anorexia. Persistent vomiting by the fourth day. There is bloody diarrhea within a few days of vomit

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ing onset. The diarrhea is often bright yellow color. There are enlarged lymph nodes.

Tomatoes and Tomato Plants: These contain atropine which can cause dilated pupils, tremors and irregular heartbeat. The highest concentration of atropine is found

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

n the leaves and stems of tomato plants, next is the unripe (green) tomatoes and then the ripe tomato.

There are more. For a complete list visit http://mooreshaven.com/pets/dogs/safety/badfoodslist.html

May all your four-legged children be healthy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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