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Obesity is a severe and debilitating illness. It is the most common nutritional disease in pets and people; estimates suggest that up to 45% of dogs and up to 13% of cats are obese (many doctors think these estimates are quite low jud

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ging by the number of obese pets they see every day in practice.) Current medical opinion states that a pet is obese if it weighs 15% or more over its ideal weight. While pet owners often use the pet's actual weight to gauge obesity,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t is probably more accurate to use a body composition score. Body composition, measured by looking at the pet from the top and sides and feeling the areas over the ribs and spine more accurately reflects obesity than a certain magical

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

number.

Can pet owners prevent obesity? Keep in mind that most obese pets are made, not born, that way. Many owners give their pets treats and snacks and feed them whenever the pet begs for food. In essence, these owners are setti

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

g their pets up for all of the medical problems that can occur with obesity. While many people who constantly reward these begging behaviors believe that they are being kind and loving owners, they are actually killing their pets with

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

kindness.

Problems that are associated with obesity in pets and people are numerous and include orthopedic problems (including arthritis,) rupture ligaments, intervertebral disk disease, difficulty breathing, reduced capacity for exer

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ise (and in severe cases any movement at all,) heat intolerance, increased chance for complications due to drug therapy (it is more difficult to accurately dose medications in obese pets,) cardiac problems, hypertension, and cancer. W

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hen you keep in mind that the excess body fat occurs in the body cavities of the chest and abdomen (often being deposited there first) as well as under the skin (what we see as "fat",) it is not surprising all of the medical problems t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

at can be associated with obesity.

Because diseases such as hypothyroidism and diabetes mellitus can be associated with obesity, obese pets should be screened for these disorders prior to treatment for obesity

The treatment of obesit

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

involves restricting calories and increasing the metabolic rate via a controlled exercise program. Using store bough "Lite" diets is not usually adequate, as these diets are not designed for weight loss but rather weight maintenance.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Additionally, since many store bought diets may contain chemicals, by-products, and fillers, they would not be a part of a holistic pet program. Homemade restricted calorie diets would be the first choice for dietary therapy for obes

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

pets (see my book The Natural Health Bible for Dogs & Cats for an example of a homemade diet for overweight pets;) processed "obesity-management" diets available through veterinarians would be the second best choice as some of these d

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ets may also contain chemicals, by-products, and fillers. These "obesity-management" diets are used until the target weight is obtained, then replaced with a homemade maintenance diet if possible. Foods which increase metabolism such

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s vegetables which are high in fiber are included in weight loss diets. Fiber, contained in vegetables, decreases fat and glucose absorption; fluctuating glucose levels cause greater insulin release. Since insulin is needed for fat s

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

torage, decreased or stable levels are preferred. Fiber also binds to fat in the intestinal tract and increases movement of the food in the intestines, which is of benefit to the obese pet.

There are several natural therapies that ma

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

be helpful as part of the treatment of obesity in some pets. Suggested therapies include chromium, carnitine, herbs (cayenne, ginger, and mustard,) hydroxycitric acid (HCA,) white bean extract, epigallocatechin gallate (EGCG,) and coe

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

zyme Q-10. The natural treatments are widely used with variable success but have not been thoroughly investigated and proven at this time. However, a new supplement that appears promising contains the clinically tested starch blocker P

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ase 2 pet®, which is an extract of white bean. Phase 2 pet® is shown to cut starch digestion up to 75%. Also in the formula is EGCG from green tea extract which boosts metabolism, inhibits carbohydrate digesting enzymes, helps maintain

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

normal blood insulin levels (which promotes the burning of fat,) and helps to control appetite, which helps support weight loss and weight management. Chromium polynicotinate is a niacin-bound chromium, that supports appetite control,

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

uilding of muscle, and the burning of fat. Finally, as with people, a regular program of supervised exercise is also important for pets on a weight reduction program. Using these ideas will help your pet get that old, slim figure back

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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