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Your dog needs a balanced diet of protein, carbohydrates and fats to maintain good general health, a healthy skin and coat, and plenty of energy. Broad guidelines

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

are: 20-25% protein, 20-35% fat and 40-60% carbohydrate. Like humans, they need vitamins and minerals, though unlike us their need for Vitamin C is satisfied by th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ir ability to synthesize it for themselves. Essential vitamin B1, however, is not stored by dogs, and can be lost in food processing. It may need to be supplied as

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

a supplement.

Just feeding your dog lean meat does not satisfy these guidelines. In nature, dogs will eat all of their prey, including fat and the contents of th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

gut, which as a whole provides close to this ideal balanced diet. In fact, dogs in the wild have been observed to prefer to eat the gut of their prey first. Studi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s have confirmed this preference in domestic dogs, by showing they generally prefer their food cooked, warm, wet and ground up rather than in raw meaty chunks. Dog

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s are not delicate eaters, however. As natural scavengers, they will eat almost anything when they are hungry, and will naturally gulp down large meals quickly whe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

food is available. Their ancestors never knew when next they might get an opportunity to eat.

Commercially processed and balanced dog food is commonly fed to dog

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s to help meet their ideal requirements, incorporating the necessary vitamin and mineral supplements. Often these foods come in dry form for ease of storage, or in

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

cans or sausages, and offer a simple and convenient solution that is popular with a high proportion of dog owners. The commercial pet food business is today a huge

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

industry. Store bought commercial dog foods are not always cheap, however.

An alternative for dog owners is to mix their own balanced dog food diet. It’s tricky t

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

o get the right combination of the right foods. Human diet guidelines are not necessarily appropriate. You will have to read up on the subject to know what you are

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

doing. To give one example of the unique dietary issues to consider, including too much dried skim milk powder could cause scouring because of its high lactose con

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tent that dogs find difficult to digest. Recipes that offer guidance are readily available should you choose to take this approach.

Dogs like to chew on large bon

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s, but small bones and cooked bones that may splinter should be avoided. They are a common cause of death for dogs when ingested. Cooked chicken, lamb chop and fis

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

bones are especially dangerous. Scraps from the table are always popular with dogs, and feeding your dog after you have eaten is one of the strategies you should

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

adopt to assert your “alpha” position in the “pack.” But do watch out not just for small bones, but also for other dangers they may contain, like toothpicks.

An a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

pect of dog behavior is that they will learn to associate a particular food with a bad experience, such as a digestive upset, and, as a natural survival instinct,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

may never eat it again. This may explain the frustrating and mysterious aversions to some foods that dog owners occasionally observe.

Feeding your seemingly raven

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

us dog is a little more complicated than it appears to be at first glance, but rarely presents any difficulty once you are aware of the unique requirements of dogs

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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