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The Christmas season is just around the corner. Because of that, the airwaves are filled with joyous Christmas carols that everybody enjoys. And one good selectio

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

n of Christmas carols are those classified as funny or laughingly infectious.

Good examples of this are the carols sung by Alvin and the Chipmunks. They have qui

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e a selection of funny Christmas carols and lyrics that would appeal to both young and old alike. More specifically, these songs are:

1. The Chipmunk Son

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

. This song has a subtitle of "Christmas Don't Be Late". The famous group, Alvin and the Chipmunks sung this song together with their human confidant, Da

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

id Seville. It was Ross Bagdasarian, Sr. who wrote this piece. Consequently though, he is the same person as David Seville. This is quite a short Christmas song,

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

omposed of only two paragraphs. But it did hit the charts and became number one during its release in 1958.

2. All I Want for Christmas Is My Two Front T

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

eth. Donald Yetter Gardner wrote this song in 1944. He was then a music teacher in Smithtown in New York. The song was written in about 30 minutes at mos

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

but it did become a certified hit. Gardner had described this particular song to be a rather silly one. But then again it was picked up by carolers of all ages.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

side from Alvin and the Chipmunks, Nat King Cole, The Platters, and Mariah Carey have all recorded this song.

3. Here Comes Santa Claus. Gene Au

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ry wrote the song and placed the necessary melody for it. This is a long song, which is composed of four paragraphs in all. The refrain that goes "Here comes Sant

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Claus, Here comes Santa Claus, Right down Santa Claus lane" is repeated after every stanza.

4. Up On The House Top. This song is yet another so

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ng that Alvin and the Chipmunks made their own. This piece is part of Chipmunk's Greatest Christmas Hits. The album is released in 1998 and had soon become a seas

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n's favorite, especially by the younger generations.

5. It's Beginning to look a lot Like Christmas. This is an example of a song sung by Alvin,

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Theodore, and Simon that includes their comrade Dave. Like "All I Want for Christmas Is My Two Front Teeth", this piece was also sung by singing greats like Johnn

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Mathis, Perry Como, and The Fontaine Sisters.

6. Hang Up Your Stockin'. This is one more funny Christmas song favorite. The song is a part of t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e Christmas with the Chipmunks Volume 2 CD under Capitol Records. The CD was originally released in 1963 and was reissued in 1991.

7. Twelve Days of Chri

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

tmas. Alvin and the Chipmunks have their own version of the famous "12 Days of Christmas" Christmas Carol. You would be amazed, and would actually smile

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t the twists in the Chipmunk's rendition of this particular song.

8. Jolly Old Saint Nicholas. Kids of all ages surely knew this one. It is a si

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ple song of a child asking for a gift from Santa Claus, who is fondly referred to as Jolly Old Saint Nicholas.

These are the most popular funny Christmas songs a

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

d lyrics as rendered by the equally famous Alvin and the Chipmunks. So the next time you are looking for these kinds of songs, you now know which artist to select

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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