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Business Dump - Slab-On-GradeConcrete Foundations
Slab-on-grade foundations are concrete slabs poured directly on the ground with no space between the ground and the concrete. This most often occurs in areas where the ground is not subject to freezing and therefore not likely to heave. There are derivations of this where frost underneath the structure is contr
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
olled with foam insulation or hydronic (hot-water) heating systems incorporated into the slab to prevent the ground below from freezing. However, it is usually not typically economically favorable to use the slab-on-grade in very cold climates. There is at type called a Frost protected Slab that is standard in Sweden and is ga
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
ining acceptance here.
The advantages of slab-on-grade are that it is a relative inexpensive form of residential foundation, they are very sturdy when properly designed and constructed and helps obstruct termites from entering the house. When properly constructed they offer very few spaces in the foundation itself for termites
The advantages of slab-on-grade are that it is a relative inexpensive form of residential foundation, they are very sturdy when properly designed and constructed and helps obstruct termites from entering the house. When properly constructed they offer very few spaces in the foundation itself for termites
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
to intrude into the structure from below. This assumes that all pipe penetrations are properly sealed with stainless steel wool or adequate caulk to prevent their passage. It also reduces the amount of perimeter crack that is vulnerable to infestation making treatment easier in the event that termites do get into the house.
Y
Y
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ou must plan carefully for utility penetrations through the slab for water, electric, gas, telecommunications and any other utilities. This is often times overlooked, especially because we fail to account for changes in technology.
When planning a slab-on-grade foundation, you must bring a conduit from underneath to an accessi
When planning a slab-on-grade foundation, you must bring a conduit from underneath to an accessi
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
ble place outside for water. Most plumbers will direct bury the line or embed the copper lines directly in the slab. This is not a good practice because it makes repair costly and difficult if something goes wrong with the water line. If you install a 2' PVC conduit for the water line, a new one can be pulled in later if you ne
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
ed to. This will also prevent the copper or galvanized water line from degrading from contact with bare concrete.
The same procedure needs to be followed for cable and telephone. You can put both services in the same conduit in this case so one 2' conduit should adequately suffice in this case. Electrical services must enter a
The same procedure needs to be followed for cable and telephone. You can put both services in the same conduit in this case so one 2' conduit should adequately suffice in this case. Electrical services must enter a
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
disconnect on the exterior of the house so it is not typical that you will need to provide a conduit under the slab for this. In all these cases, the conduit should terminate in one central location in the house such as a utility closet or garage.
Structural Characteristics
Slab-on-grade design calls for a sl
Structural Characteristics
Slab-on-grade design calls for a sl
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
ab thickness a minimum of 4" thickening to a minimum of 6" within about 16" of the perimeter for additional reinforcing steel to support exterior wall loads. If there is to be a interior bearing wall, the engineer will also call for this area to be thickened and more reinforcing
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
to compensate for these loads.
Perimeter footers and interior footers or rafts are typically reinforced with steel bars called re bar. This adds tremendous strength to the concrete by compensating for the concretes poor tensile strength. By combining steel with concrete, you combine two incredibly strong materials in a way tha
Perimeter footers and interior footers or rafts are typically reinforced with steel bars called re bar. This adds tremendous strength to the concrete by compensating for the concretes poor tensile strength. By combining steel with concrete, you combine two incredibly strong materials in a way tha
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
t compensates for the weak characteristics of each.
You will also see what is called WWF (welded wire fabric) also called as reinforcing in concrete but its true purpose is to distribute temperature changes in the concrete more evenly to prevent cracking, the proper term is controlling crackin
You will also see what is called WWF (welded wire fabric) also called as reinforcing in concrete but its true purpose is to distribute temperature changes in the concrete more evenly to prevent cracking, the proper term is controlling crackin
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
g. I say prevent cracking, but you will still have cracking in concrete, it is the nature of concrete to crack, so another step taken to minimize the effect of cracking is the process of placing control joints at specified intervals to guide the cracks to the bottom of the crack where they will not be seen and to minimize the t
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
ravel of any one crack. If you see minor cracks in the bottom of the control joint, do not panic, it is normal. The design and placement is very important to the integrity of the slab. Discuss this in detail with your selected concrete sub to make sure adequate control joints are placed in the slab.
Proper Construction
Proper Construction
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Means Proper Curing
The key to a good slab-on-grade foundation that has been properly designed is to allow time to wet cure the concrete. Concrete is poured as liquid, but begins to harden immediately. It is usually hard enough to walk on in a day. It should not be built on for a minimum for seven da
The key to a good slab-on-grade foundation that has been properly designed is to allow time to wet cure the concrete. Concrete is poured as liquid, but begins to harden immediately. It is usually hard enough to walk on in a day. It should not be built on for a minimum for seven da
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
s and you must take care that the temperatures are not too cold or too hot when you pour it. The benefits of proper curing are:
Increased strength gain
Increased abrasion resistance on the surface
Less permeable concrete with increased resistance to chloride penetration and freeze/thaw damage
Increased resistance to early c
Increased strength gain
Increased abrasion resistance on the surface
Less permeable concrete with increased resistance to chloride penetration and freeze/thaw damage
Increased resistance to early c
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
racking--slabs gain strength before drying out and have more resistance to shrinkage forces.
So what is a proper method of curing. Well in warm climates, it entails keeping the concrete damp for a minimum of 7 days. This is accomplished by spraying water on the slab every day (twice a day if needed) spraying the concrete and c
So what is a proper method of curing. Well in warm climates, it entails keeping the concrete damp for a minimum of 7 days. This is accomplished by spraying water on the slab every day (twice a day if needed) spraying the concrete and c
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
overing it with plastic sheeting to retain the water within or using some other medium (kept wet) such as sand, straw, or blankets to do this function for at least 7 days, the longer the better. With proper planning this will be possible although if you are working with a builder, he will probably want to start framing as quick
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
as possible after the slab is poured. Do yourself a favor and allow the 7 days for proper curing and make sure that adequate methods are employed to retain moisture in the slab during the process.
The last 2 important considerations are temperature when pouring. Concrete generates tremendous heat during the curing stage. If i
The last 2 important considerations are temperature when pouring. Concrete generates tremendous heat during the curing stage. If i
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
t is poured at very high temperatures (over 95 'F) you must take special precautions to mitigate the heat, talk with your contractor if you suspect you will have this condition to make sure he is prepared to take the proper steps to protect the concrete. Concomitantly, you should not pour concrete when the temperature is below
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
20 'F unless you are prepared to maintain heat on the slab until it has fully cured. This will be very expensive to do so it is best to not pour when temperatures are going to be below freezing for extended periods. You can do it , but you must make sure to maintain the internal temperature of the concrete at no less than 55 'F
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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