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I was helping my daughter having her kitchen remodelled recently. She was having problems trying to decide on a new countertop material. Walking through the counter

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s area in Home Depot gave her a few ideas, but she was still undecided when the time came to choose a month later. I decided to write out a quick comparison of all

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

he materials and costs for her and when I was done I thought other people might find it useful as well, so here goes.

Most people are familiar with laminate counte

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tops. (Formica is one brand name.) They’re a thin surface of high-pressure laminate applied to a thicker base of plywood or particleboard. Pluses: The standby, avai

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

able in literally hundreds of patterns and colors, laminates are the least expensive (next to tile) and durable, requiring less upkeep than tile. Minuses: Easy to s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

orch with hot cookware, the use of layers in their construction makes it tricky to repair chips, show scratches, especially lighter colors, so not usable as a cutti

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

g surface. Less durable than natural stone or solid surface; use with under mount sinks is not recommended. Cost: $25 to $50 foot

Solid surfacing, (brand names Co

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rian, Fountainhead, Avonite and Surrell) a newer countertop material, is durable and mimics the appearance of natural stone materials like marble or granite. Pluses

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

Gives seamless surfaces, easy to care for. High impact resistance, easily repaired, nonporous and seamless, so won't trap dirt, collect bacteria or stain; easily.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

inuses: May melt from hot pot; looks non-natural in some color schemes, licensed contractor required for installation and repair work. Cost: $60 to $110 per foot.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

atural woods. Used in butcher-block style arrangement. Maple, oak and other hardwoods, make durable and elegant countertops. Pluses: Good surface for cutting foods;

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

scratches easily repaired by sanding; easy match with wood cabinets and floors. Minuses: Requires a finish to preserve appearance, may scorch with hot cookware, all

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ws bacterial growth, so needs regular cleaning. Not practical for entire countertop – good for small sections. Cost: $50 to $75 per foot

Granite. Popular for their

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

elegant and rich look, natural stone countertops will last longer than most kitchens. Pluses: Adds to value of home, hard durable surface, very heat resistant. Minu

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ses: very expensive, requires care since it is porous and must be sealed periodically, grease will stain. Cost: 60 to $200 per foot for granite $60 to $130 per foot

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

for marble (stains easily and not recommended for food prep countertop)

Ceramic or Porcelain Tile: This is the countertop material my daughter was replacing. While

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the counters were in pretty bad shape, refurbishing was an option. Tile has a comforting, classic look and is inexpensive.. Pluses: Easy to clean up after a mess.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ore heat resistant than laminates solid surfaces, inexpensive, unless you are thinking about custom or hand-painted tiles. Minuses: Can chip and crack easily; needs

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

regular maintenance to keep bacteria out of grout. Scrubbing grout. Cost: $10 to $25 per foot.

So, what countertop material did she choose in the end? For it’s rea

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

onable cost and reparability, Corian got the nod for the new kitchen. We found a color that was very close to a granite look and we also liked the ten year warranty

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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