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When arriving at your destination, there is nothing worse than having to deal with a tired and fatigued frame of mind caused by je

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t lag.

What is Jet Lag?

Your body’s biological clock can become ‘desynchronised” when you travel at a fast pace through several

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ifferent time zones. Although the symptoms of jetlag are often only minor (such as tiredness of the body and mind), it can be a dr

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

in on the first few days of your trip.

Prepare Yourself for Jet Lag

Whether you travel frequently or recreationally, it is impor

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ant to follow some precautionary advice when crossing several time zones. As it may take a few days to acclimatise to a new time z

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ne and you need to plan ahead. This will allow you to synchronize your body clock with the time zone to which you are traveling.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

hen crossing these time zones, take the time to follow these steps:

• Try going to bed earlier a couple of nights before you trav

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

l east. Try going to bed later if you plan to travel west
• If you are going west, try to get bright natural light in the ear

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

y evening. This may help you adjust to eastern time zones much easier
• Get a good night’s sleep! During long overseas flight

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

, try to get some shut-eye before you arrive at your destination
• Try not to smoke, drink, or take sleeping pills while in f

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ight. These things will merely make you feel worse when you finally arrive
• Drink lot’s of water before, during, and after y

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ur flight to avoid possible dehydration
• Try to exercise while in flight. Stretching in your cabin seat or walking around ca

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

prevent stagnation of blood circulation. Older travellers should especially do this to prevent swelling in the feet.

Watch

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ut For Symptoms of Jet Lag

Jet lag can affect many aspects of your body’s daily routine. The symptoms of jet lag can include head

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ches, irritability, insomnia, difficulty concentrating, and loss of appetite. These symptoms are usually more severe for those fly

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ng east rather than west, and the severity of these symptoms will depend on how many time zones you cross.

What to Do When You Ar

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ive

When you arrive at your destination, try to adopt local hours for sleep by following these steps;

• Activate your mind as sw

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ftly as possible after waking.
• Get outside, or at least open the windows. This will expose you to as much natural daylight

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s possible. Natural daylight will help you adjust to the proper time zone faster and more effectively.
• Try to forget that

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ou are adjusting to a new time zone and convince yourself that it is 12:00 o’ clock in the afternoon rather than 8:00pm last night

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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